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GENEQUERY 人CTLA4 检查点通路QPCR 分析试剂盒

英文名:GeneQuery? Human CTLA4 Checkpoint Pathway qPCR Array Kit

货号:GK122

价格:$240

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ScienCell's GeneQuery? Human CTLA4 Checkpoint Pathway qPCR Array Kit (GQH-CTL) is designed to facilitate gene expression profiling of 88 key genes involved in the human CTLA4 checkpoint pathway and to help identify potential prognostic biomarkers for cancer immunotherapy.  CTLA4 is a negative regulator of T cell immune function. It regulates T cell priming in the initial stage of antigen stimulation. CTLA4 can antagonize CD28 signaling in T cells, as CTLA4 and CD28 compete for the same binding ligands, CD80 and CD86. Cancer immunotherapy using CTLA4 immune-checkpoint blockade (ICB) has emerged as a promising strategy to activate antitumor T cell responses, and has led to new immunotherapies for  various solid and hematological tumors. Brief examples of how genes may be grouped according to their functions are shown below:     

  •   CTLA4 downstream immune response:  ZAP70, TRAT1, PTPN11, PIK3R1, PLD1, ARF1, NFKB1, NFATC2, JUN, FOS, BCL2
  •   CD28 signaling:  NFATC2, NFKB1/2, GRB2, VAV1, PTPN6, PI3Ks, SNX9, MALT1, CARD11, BCL10, GRAP2
  •   AKT signaling / Cell survival:  AKT1/2/3, PTPN2, PTPN6, PTPN11, CDKN1B, BCL2L1, PDPK1, PIK3CA, PIK3CG
  •   Co-stimulatory/inhibitory pathway / T cell activation:  CTLA4, CD28, CD80, CD86, PDCD1, CD274, CD276, CD8, CD3, CD4, ICOS, CD27, PDCD1LG2, TNFRSF4/9/18, CSK, LCK, PTCRA
  •   Other T cell markers: BATF, BCL6, CCR6, CD44, CD69, CXCR3/5, HLA-ABC, ICOSLG, IL2RA, IL7R, SELL

Noteall gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).

货号GK122
产地美国
缩写GQP-CTL
规格
用途科研
储存4°C
运输胶冰
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