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重组人肿瘤坏死因子-alpha Variant rhTNF-α variant

英文名:Recombinant Human Tumor Necrosis Factor-alpha Variant

货号:103-01v

价格:$79

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The clinical use of the potent antitumor activity of TNF-α has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-α55 but not to the murine TNF-α75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-α55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.
货号103-01v
产地美国
缩写rhTNF-α variant
规格10ug
用途科研
储存-20度
运输干冰
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